4-Oxo Retinoic Acid for Refractory Acute Promyelocytic Leukemia in Children with All-Trans Retinoic Acid Therapy.
نویسندگان
چکیده
منابع مشابه
Acute Promyelocytic Leukemia: All-Trans-Retinoic Acid Era
Acute promyelocytic leukemia (APL) is highly curable with the combination of all retinoic acid (ATRA) and anthracycline based chemotherapy, but the percentage of early deaths remains high. In the present study, we report the clinical, immunophenotypi molecular characteristics and outcome of APL patients diagnosed and treated in various Hospitals of Greece and Cyprus. We describe the data of nin...
متن کاملMassive ascites associated with all-trans retinoic acid treatment in therapy-related acute promyelocytic leukemia.
A 77-year-old man who developed pancytopenia was administered granulocyte colony-stimulating factor (G-CSF) by another doctor, and referred to us for the evaluation of pancytopenia. He had hepatocellular carcinoma and was treated with transcatheter arterial chemoembolization (TACE) containg epirubicin (total dose: 300 mg over the last two years). Bone marrow aspiration smear demonstrated hyperc...
متن کاملMolecular evaluation of response to all-trans-retinoic acid therapy in patients with acute promyelocytic leukemia.
The advent of retinoic acid (RA) in the treatment of acute promyelocytic leukemia (APL) has led to a high frequency of short-lasting complete remissions (CR). We studied the response to RA by molecularly analyzing the RA receptor alpha (RAR alpha) locus, which has recently been shown to be rearranged in all APLs. Southern blot analysis demonstrated that the RAR alpha rearrangements persisted in...
متن کاملDiagnostic immunophenotype of acute promyelocytic leukemia before and early during therapy with all-trans retinoic acid.
OBJECTIVES To study the immunophenotypic changes of acute promyelocytic leukemia (APL) in patients who recently received all-trans retinoic acid (ATRA) and to assess the diagnostic utility of flow cytometry in this setting. METHODS Flow cytometry was performed on 29 newly diagnosed APLs and 93 other acute myeloid leukemias, including 25 HLA-DR- or CD34- cases. Clinical notes from referring in...
متن کاملAll-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results.
Twenty-two patients with acute promyelocytic leukemia were treated with all-trans retinoic acid (RA, 45 mg/m2 per day) for 90 days. Of the 22, four patients were previously untreated, two were resistant after conventional chemotherapy, and 16 were in first (n = 11), second (n = 4), or third (n = 1) relapse. We observed 14 complete response, four transient responses, one failure, and three early...
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ژورنال
عنوان ژورنال: Journal of Nutritional Science and Vitaminology
سال: 1995
ISSN: 0301-4800,1881-7742
DOI: 10.3177/jnsv.41.493